Team Leader:

Dr. Qing-hua Chen, Professor, Ph.D. supervisor

Team Member:

Dr. Ming-hua Huang, Associate Professor, Master supervisor

Dr. Chong-yan Leng Associate Professor, Master supervisor

Dr. Ting-ting Yan, Associate Professor, Master supervisor

Dr. Xi-liang Chen, Lecturer

Dr. Jin-kun Liu, Lecturer

General Information

Innovative research team of functional biomaterials is awarded as one of the key research teams of discipline construction in KUST. The whole team is engaged in the development of new functional biomaterials which can be specifically divided as: I) bone repairing materials and their scaffolds for bone tissue engineering, II) porous organic-fiber materials and reinforced composites as cartilage tissue engineering scaffolds, III) organic-inorganic hybrids based on nano-hydroxyapatite for the remineralization of dental enamel; IV) organic porous membranes and derivatives as skin regeneration materials; V) modified PMMA bone cements for long-term stabilization of implantation. Principal activities in the research team cover the structure and morphology design, preparation and characterization, physical properties testing and biological performance evaluation. Except foundational scientific researches, the team also constantly carries out the medium scale pilot production for the future commercialization of potential materials.

Up to now, the innovative research team of functional biomaterials has assembled 6 core members, undertook more than 20 national-level and provincial-level research projects, the research funding sums up to 2 million Chinese RMB. Under the funding’s support, the research team has cultivated 1 doctor, 25 masters and more than 200 undergraduates. Over 100 scientific research papers have been published and 20 of the 60 applied patents have been authorized. The team owns 2 preparation rooms and 1 ultra-clean cell-culturing lab, existing experimental facilities and equipment is enough to satisfy the preparation of material and in vitro assay of the bioactivity, cytotoxicity and cell adhesion. Besides that, the research team has also established a deeper cooperation with several medical institutions who can provide standardized animal experiment and professional evaluation for the physiological performance in vivo of biomaterials. Recently, the achievements of medium scale pilot production attracts the investment from the enterprise, the research team has signed the R & D contract with Yunnan Baiyao Group Co., Ltd to exploit new dental materials applied for the prevention and cure of dental caries.

Our research team welcomes any person who possesses the great interest in functional biomaterials area. Contact us as you wish to start your career here.

Specific Research Orientation

  1. Bone Reconstruction Materials and Scaffolds

  2. Cartilage Tissue Engineering Scaffolds

  3. New Dental Repairing Materials

  4. Skin Repairing Materials

  5. Surface Bioactivity Modification Design

Experimental facilities

The research team has already built two workshops for sample preparation and one ultra-clean cell culturing lab for the assay of cytotoxicity and cell adhesion.

Cooperation

  1. Department of orthopedics of Kunming General Hospital of Chengdu Military Area

  2. Department of burns of the 2nd Affiliated Hospital of Kunming Medical College

  3. Affiliated Stomatological Hospital of Kunming Medical University

  4. Yunnan Baiyao Group Co., Ltd

Ongoing Research Projects

  1. Cooperative R & D projects of the enterprise, Research on the preparation of Amino Acids/ Collagen modified nano-hydroxyapatite composites and their induction mechanisms on the remineralization of dental enamel, 2017/01 ~ 2019/12

  2. National Nature Science Foundation of China (No. 31260228), Study on the Sodium hyaluronate / Konjac glucomannan Fibrous Scaffold, 2013/01 ~ 2016/12

  3. Yunnan Provincial personnel training project, Bioactivity modification of PMMA bone cement based on the combination of Ca²⁺ ions and phosphate-containing monomer, 2016/05 ~ 2019/04

  4. Youth Project of Yunnan Provincial applied basic research plan, Research on the PMMA bone cement modified with strontium-substituted hydroxyapatite whiskers, 2017/05 ~ 2020/05

Selected Publications

[1] Yun Lei, Jin-kun Liu, Ting-ting Yan, Qing-hua Chen* et al. Preparation of Dental Resin Based Composites by Surface Modified Hydroxyapatite Whisker, Journal of Synthetic Crystals, 2017, 46(3): 422-426

[2] Si-yu Wu, Ting-ting Yan, Jing-jing Xu, Qing-hua Chen*, et al. Preparation and Properties of Porous Biphasic Calcium Phosphate Bone Tissue Engineering Scaffold, Journal of Synthetic Crystals, 2016, 45(6): 1653-1658

[3] Jing-jing Xu, Xi-liang Chen, Yan-ting Yin, Qing-hua Chen*, et al. Research on Preparation and Performance of Magnetic Modified HAP/CS/SiO₂ Bone Tissue Engineering Scaffolds, Journal of Synthetic Crystals, 2016, 45(6): 1683-1690

[4] Ting-ting Yan, Si-yu Wu, Qing-hua Chen, et al. In vitro Corrosion Resistance of AZ31B Magnesium Alloy after Phosphating Treatment, Journal of Materials Protection, 2016, 49(5): 5-7+22

[5] Qiang-guo Chen, Ting-ting Yan, Ming-hua Huang, Qing-hua Chen*, et al. Application of Polyurethane Foam Powder in Hydroxyapatite Whisker Porous Ceramic Materials, Journal of Synthetic Crystals, 2016, 45(3): 778-782+788

[6] Jie Huang, Ting-ting Yan, Qing-hua Chen*, Jin-kun Liu, et al. Preparation of Hydroxyapatite Whisker Honeycomb Scaffolds via Foaming Method, Journal of Synthetic Crystals, 2016, 45(2): 2862-2865

[7] Yan-ting Yin, Qing-hua Chen*, Ting-ting Yan. Synthesis of silica modified large-sized hydroxyapatite whiskers by a hydrothermal co-precipitation method. Key Engineering Materials, 2015, 645~646: 1339-1344

[8] Shi-gang Tao, Duan-cheng Wang, Ting-ting Yan, Qing-hua Chen*, et al. Preparation and properties of chitosan-hydroxyapatite /Fe₃O₄ magnetic nano-carriers, Journal of Functional Materials, 2015, 46(11): 11139-11143

[9] Ming-hua Huang, Qing-hua Chen*, Ting-ting Yan, et al. Study on Nano Hydroxyapatite /Collagen /KGM Porous Bone Scaffolds, Journal of Synthetic Crystals, 2015, 44(7): 1961-1967

[10] Duan-cheng Wang, Ting-ting Yan, Ming-hua Huang, Qing-hua Chen*, et al. Preparation of Barium-doped Hydroxyapatite Whisker, New Chemical Materials, 2015, 43(5): 38-39+46

[11] Zhen Li, Wei-bo Zhu, Yan-ting Yin, Ting-ting Yan, Qing-hua Chen*, et al. Preparation and Morphology of Chitosan/Konjac Glucomannan/Sodium Hyaluronate Blend Porous Membrane, Polymer Materials Science and Engineering, 2015, 31(5): 159-168

[12] Tian-you Kong, Ting-ting Yan, Yan-ting Yin, Qing-hua Chen*, et al. Effect of pH Value and Sintering Temperature on Property ofβ-Tricalcium Phosphate Powders, Journal of Synthetic Crystals, 2015, 44(3): 746-750

[13] Qiang-guo Chen, Qing-hua Chen*, Chong-yan Leng, Ting-ting Yan, Xi-liang Chen, et al. Investigation of Polyvinyl Alcohol/Sodium Hyaluronate Fibers Scaffolds Materials，Materials Review：Nano and New Materials Edition，2015, 29(2): 403-405+436

Authorized Patents

[1] Qing-hua Chen, Zhen Li, Ting-ting Yan, Chong-yan Leng. One Preparation Method of micro-nano level Konjac Glucomannan (KGM) Fiber Scaffold Material, 2016.10.26, Patent No. 201510135245.X

[2] Qing-hua Chen, Zhen Li, Ting-ting Yan. One Porous Composite Scaffold Material for Bone Tissue Engineering Composite and Its Preparation Method, 2016.06.28, Patent No. 201410181547.6

[3] Qing-hua Chen, Wei-bo Zhu, Ting-ting Yan. One Preparation Method of Konjac Glucomannan (KGM) Fiber Scaffold Material, 2015.09.09，Patent No. 201310526620.4

[4] Qing-hua Chen, Yong-shun Cui, Li Lei, Ming-hua Huang, Ting-ting Yan, Chong-yan Leng. One Monetite Whisker and Its Preparation Method. 2015.06.03, Patent No. 201210528679.2

[5] Qing-hua Chen, Wei-bo Zhu, Ting-ting Yan. One Membrane Material for Drug Controlled Releasing and Preparation Method, 2015.01.28, Patent No. 201310526620.4

[6] Qing-hua Chen, Yin Li, Ting-ting Yan, Chong-yan Leng. One Fiber Scaffold Material for Cartilage Tissue Engineering and Its Preparation Method, 2014.09.03, Patent No. 201210528821.3

[7] Qing-hua Chen, Yin Li, Ting-ting Yan, Chong-yan Leng. One Postoperative Adhesion Membrane Material and Its Preparation Method 2014.08.06, Patent No. ZL 201210528603.X

Contact

Bio-engineering Material Laboratory, Faculty of Materials Science and Engineering, Kunming University of Science and Technology
Address: Room635 in New Building of Faculty of Materials Science and Engineering in Lianhua campus, No.68 Wenchang Road, 121 Street, Kunming. Zip code: 650093

Email: chenqinghua_yn1@163.com or 847501438@qq.com, Mobile phone: +86 13888013957